Hydrogen therapy is more effective than oxygen therapy in COPDScientific Research

DOI: 10.1186

Published on: 13/05/2021

Authors:

Зе-Гуан Джън ,
Wu-Zhuang Sun ,
Джи-Ин Ху ,
Джи-Джун Джи ,
Джин-Фу Сю ,
Джи Цао ,
Песен на Юан-Лин ,
Чанг-Хуей Уанг ,
Дзин Уанг ,
Хуей Джао ,
Zhong-Liang Guo &
Нан-Шан Чжун

Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial

https://doi.org/10.1186/s12931-021-01740-w

Abstract

Background

To investigate whether the use of a hydrogen/oxygen mixture is superior to oxygen in improving symptoms in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).

Methods

This prospective, randomized, double-blind, controlled, 10-center clinical study enrolled patients with AECOPD and a BCSS (dyspnea, cough and sputum scale) score of at least 6. Eligible patients were randomly assigned (1:1 ratio) to receive hydrogen/oxygen hybrid therapy or oxygen therapy. The primary endpoint was change from baseline in BCSS score at day 7. Adverse events (AEs) were recorded to assess safety.

Results

The change in BCSS score was greater in the hydrogen/oxygen group than in the oxygen group (-5.3 vs. -2.4 points; difference: -2.75 [95% CI -3.27 to – 2:22], which met superiority criteria). Similar results were observed at other time points from day 2 to day 6. Cough assessment test scores were significantly lower in the hydrogen/oxygen group compared to the control group (-11.00 vs -6.00, p<0.001). Changes in lung function, arterial blood gases, and noninvasive oxygen saturation did not differ significantly between groups, as well as for other endpoints. AEs were reported in 34 (63.0%) patients in the hydrogen/oxygen group and in 42 (77.8%) patients in the oxygen group. No deaths or equipment failures were reported during the study period.

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