Hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetesScientific Research

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28:137-43.

Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, et al.

Abstract

Oxidative stress is widely recognized to be associated with a variety of disorders, including diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a reducing effect. Therefore, we investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism in patients with type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We performed a randomized, double-blind, placebo-controlled, crossover study in 30 T2DM patients controlled by diet and exercise and 6 patients with IGT. Patients consumed either 900 ml/d of pure hydrogen-rich water or 900 ml of pure placebo water for 8 weeks, with a 12-week washout period. Several biomarkers of oxidative stress, insulin resistance, and glucose metabolism assessed by oral glucose tolerance test were assessed at baseline and at 8 weeks. Intake of hydrogen-rich water was associated with significant reductions in levels of modified low-density lipoprotein (LDL) cholesterol (i.e., modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15, 5% (P < .01), 5.7% (P < .05), and 6.6% (P < .05), respectively. Intake of hydrogen-rich water was also associated with a trend toward decreased serum concentrations of oxidized LDL and free fatty acids and increased plasma levels of adiponectin and extracellular superoxide dismutase. In 4 of 6 patients with IGT, ingestion of hydrogen-rich water normalized oral glucose tolerance. In conclusion, these results suggest that hydrogen-rich water supplementation may have a beneficial role in preventing T2DM and insulin resistance. Intake of hydrogen-rich water was associated with significant reductions in levels of modified low-density lipoprotein (LDL) cholesterol (i.e., modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15, 5% (P < .01), 5.7% (P < .05), and 6.6% (P < .05), respectively. Intake of hydrogen-rich water was also associated with a trend toward decreased serum concentrations of oxidized LDL and free fatty acids and increased plasma levels of adiponectin and extracellular superoxide dismutase. In 4 of 6 patients with IGT, ingestion of hydrogen-rich water normalized the oral glucose tolerance test. In conclusion, these results suggest that hydrogen-rich water supplementation may have a beneficial role in preventing T2DM and insulin resistance. Intake of hydrogen-rich water was associated with significant reductions in levels of modified low-density lipoprotein (LDL) cholesterol (i.e., modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15, 5% (P < .01), 5.7% (P < .05), and 6.6% (P < .05), respectively. Intake of hydrogen-rich water was also associated with a trend toward decreased serum concentrations of oxidized LDL and free fatty acids and increased plasma levels of adiponectin and extracellular superoxide dismutase. In 4 of 6 patients with IGT, ingestion of hydrogen-rich water normalized the oral glucose tolerance test. In conclusion, these results suggest that hydrogen-rich water supplementation may have a beneficial role in preventing T2DM and insulin resistance.

Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutr Res. 2008;28:137-43.