The effects of 24 weeks of high-concentration hydrogen-rich water intake on body composition, blood lipid profiles and inflammatory biomarkers in men and women with metabolic syndrome: a randomized controlled trial
Tyler W LeBaron,1,2 Ram B Singh,3 Ghizal Fatima,4 Kumar Kartikey,3 Jagdish P Sharma,3 Sergej M Ostojic,5,6 Anna Gvozdjakova,7 Branislav Kura,2 Mami Noda,8 Viliam Mojto,9 Mohammad Arif Niaz,10
doi: 10.2147/DMSO.S240122
Metabolic syndrome is associated with several medical risk factors, including dyslipidemia, hyperglycemia, and obesity, which has become a global pandemic. The consequences of this condition increase the risk of cardiovascular and neurological diseases and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and disturbances in cellular homeostasis. Molecular hydrogen (H 2 ) can reduce oxidative stress, improve cell function and reduce chronic inflammation. Preclinical and clinical studies have shown promising effects of hydrogen-enriched H 2 water (HRW) on specific features of the metabolic syndrome, but the effects of long-term high-concentration HRW in this prevalent condition remain poorly addressed.
Methods
We conducted a randomized, double-blind, placebo-controlled trial in 60 subjects (30 men and 30 women) with metabolic syndrome. An initial observation period of one week was used to obtain baseline clinical data, followed by randomization to either placebo or high-concentration HRW (> 5.5 mmol H 2 per day) for 24 weeks
Results
Supplementation with highly concentrated hydrogen water HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis compared with placebo ( P <0.05). Additionally, H 2 tended to promote a slight decrease in body mass index and waist-to-hip ratio.
Conclusion
Our results provide further confidence that HRW hydrogen water with a high concentration of hydrogen may have promising effects as a therapeutic modality for mitigating metabolic syndrome risk factors.
Published online 2020 Mar 24. doi: 10.2147/DMSO.S240122
PMCID: PMC7102907
PMID: 32273740
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial
The effects of 24 weeks of high-concentration hydrogen-rich water intake on body composition, blood lipid profiles and inflammatory biomarkers in men and women with metabolic syndrome: a randomized controlled trial
Tyler W LeBaron,1,2 Ram B Singh,3 Ghizal Fatima,4 Kumar Kartikey,3 Jagdish P Sharma,3 Sergej M Ostojic,5,6 Anna Gvozdjakova,7 Branislav Kura,2 Mami Noda,8 Viliam Mojto,9 Mohammad Arif Niaz,10
doi: 10.2147/DMSO.S240122
Metabolic syndrome is associated with several medical risk factors, including dyslipidemia, hyperglycemia, and obesity, which has become a global pandemic. The consequences of this condition increase the risk of cardiovascular and neurological diseases and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and disturbances in cellular homeostasis. Molecular hydrogen (H 2 ) can reduce oxidative stress, improve cell function and reduce chronic inflammation. Preclinical and clinical studies have shown promising effects of hydrogen-enriched H 2 water (HRW) on specific features of the metabolic syndrome, but the effects of long-term high-concentration HRW in this prevalent condition remain poorly addressed.
Methods
We conducted a randomized, double-blind, placebo-controlled trial in 60 subjects (30 men and 30 women) with metabolic syndrome. An initial observation period of one week was used to obtain baseline clinical data, followed by randomization to either placebo or high-concentration HRW (> 5.5 mmol H 2 per day) for 24 weeks
Results
Supplementation with highly concentrated hydrogen water HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis compared with placebo ( P <0.05). Additionally, H 2 tended to promote a slight decrease in body mass index and waist-to-hip ratio.
Conclusion
Our results provide further confidence that HRW hydrogen water with a high concentration of hydrogen may have promising effects as a therapeutic modality for mitigating metabolic syndrome risk factors.
Published online 2020 Mar 24. doi: 10.2147/DMSO.S240122
PMCID: PMC7102907
PMID: 32273740
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial
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