Hydrogen-rich water improves liver function in patients with chronic hepatitis BScientific Research

Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B

https://doi.org/10.1111/cts.12076

Abstract

Objective

To investigate the effects of hydrogen-rich water (HRW) on oxidative stress, liver function and HBV DNA in patients with chronic hepatitis B (CHB).

Methods

Sixty CHB patients were randomly assigned to either usual care or hydrogen therapy, in which patients received usual care alone or plus oral HRW (1200-1800 mL/day twice daily) for 6 weeks. Serum oxidative stress, liver function and HBV DNA levels were detected before and after treatment. 30 healthy volunteers served as controls.

Results

Compared with the control group, the oxidative stress and liver function were significantly impaired in patients with chronic hepatitis B. After treatment, oxidative stress remained unchanged in the conventional treatment group, but significantly improved in the hydrogen treatment group. After appropriate treatment, liver function was significantly improved and HBV DNA was significantly reduced. Although there was a significant difference in oxidative stress between the two groups after treatment, liver function and HBV DNA levels were comparable after treatment, both showing a trend of improvement.

Conclusion

HRW significantly reduced oxidative stress in CHB patients, but further studies with long-term treatment are needed to confirm the effect of HRW on liver function and HBV DNA levels. Clinical Interscience 2013; Volume #: 1-4

References

  • 1 World Health Organization. Hepatitis B. http://www.who.int/mediacentre/factsheets/fs204/en/ (accessed December, 18, 2012).
  • 2 Branch of Hepatology and Infectious diseases of Chinese Medical Association. Guideline for Prevention and Treatment of Chronic Hepatitis B (2010). J Clin Hepatol. 2011, 14(2): 81– 89
  • 3Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog. 2006; 5: 14.
  • 4Muriel P. Role of free radicals in liver diseases. Hepatol Int. 2009; 3(4): 526– 536
  • 5Farinati F, Cardin R, De Maria N, Della Libera G, Marafin C Lecis E Burra P Floreani A Cecchetto A Naccarato R. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol. 1995; 22(4): 449– 456.
  • 6Seronello S, Sheikh MY, Choi J. Redox regulation of hepatitis C in nonalcoholic and alcoholic liver. Free Radic Biol Med. 2007; 43(6): 869– 882
  • 7Ohsawa I Ishikawa M Takahashi K Watanabe M Nishimaki K Yamagata K Katsura K Katayama Y Asoh S Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007; 13(6): 688– 694.
  • 8Cai J Kang Z Liu K Liu W Li R Zhang JH Luo X Sun X. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009; 1256: 129– 137.
  • 9Kang KM Kang YN Choi IB Gu Y Kawamura T Toyoda Y Nakao A. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res. 2011; 1: 11.
  • 10Nakao A Toyoda Y Sharma P Evans M Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome: An open label pilot study. J Clin Biochem Nutr. 2010; 46(2): 140– 149
  • 11Lee WM. Cellular and humoral immunity in viral hepatitis. Am J Clin Pathol. 1976; 65(5 Suppl): 866– 869.
  • 12Yu Y Gong R Mu Y Chen Y Zhu C Sun Z Chen M Liu Y Zhu Y Wu J. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors IL-29, IL-8, and cyclooxygenase-2. J Immunol. 2011; 187(9): 4844– 4860.
  • 13Swietek K, Juszczyk J. Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis. J Viral Hepat. 1997; 4(2): 139– 141.
  • 14Tasdelen Fisgin N Aydin BK Sarikaya H Tanyel E Esen S Sunbul M Leblebicioglu H. Oxidative stress and antioxidant defense in patients with chronic hepatitis B. Clin Lab. 2012; 58(3–4): 273– 280.
  • 15Bolukbas C Bolukbas FF Horoz M Aslan M Celik H Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis. 2005; 5: 95.
  • 16Medina J, Moreno-Otero R. Pathophysiological basis for antioxidant therapy in chronic liver disease. Drugs. 2005; 65(17): 2445– 2461.
  • 17Singal AK, Jampana SC, Weinman SA. Antioxidants as therapeutic agents for liver disease. Liver Int. 2011; 31(10): 1432– 1448.
  • 18Villanueva C, Kross RD. Antioxidant-induced stress. Int J Mol Sci. 2012; 13(2): 2091– 2109.
  • 19Hong Y, Chen S, Zhang JM. Hydrogen as a selective antioxidant: a review of clinical and experimental studies. J Int Med Res. 2010; 38(6): 1893– 1903.
DOI: 10.1111

Published on: 13/06/2013

Authors:

Chunxiang Xia M.D., Wenwu Liu Ph.D., Dongxiao Zeng B.A., Liyao Zhu B.A., Xiaoli Sun B.A., Xuejun Sun Ph.D.

Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B

https://doi.org/10.1111/cts.12076

Abstract

Objective

To investigate the effects of hydrogen-rich water (HRW) on oxidative stress, liver function and HBV DNA in patients with chronic hepatitis B (CHB).

Methods

Sixty CHB patients were randomly assigned to either usual care or hydrogen therapy, in which patients received usual care alone or plus oral HRW (1200-1800 mL/day twice daily) for 6 weeks. Serum oxidative stress, liver function and HBV DNA levels were detected before and after treatment. 30 healthy volunteers served as controls.

Results

Compared with the control group, the oxidative stress and liver function were significantly impaired in patients with chronic hepatitis B. After treatment, oxidative stress remained unchanged in the conventional treatment group, but significantly improved in the hydrogen treatment group. After appropriate treatment, liver function was significantly improved and HBV DNA was significantly reduced. Although there was a significant difference in oxidative stress between the two groups after treatment, liver function and HBV DNA levels were comparable after treatment, both showing a trend of improvement.

Conclusion

HRW significantly reduced oxidative stress in CHB patients, but further studies with long-term treatment are needed to confirm the effect of HRW on liver function and HBV DNA levels. Clinical Interscience 2013; Volume #: 1-4

References

  • 1 World Health Organization. Hepatitis B. http://www.who.int/mediacentre/factsheets/fs204/en/ (accessed December, 18, 2012).
  • 2 Branch of Hepatology and Infectious diseases of Chinese Medical Association. Guideline for Prevention and Treatment of Chronic Hepatitis B (2010). J Clin Hepatol. 2011, 14(2): 81– 89
  • 3Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog. 2006; 5: 14.
  • 4Muriel P. Role of free radicals in liver diseases. Hepatol Int. 2009; 3(4): 526– 536
  • 5Farinati F, Cardin R, De Maria N, Della Libera G, Marafin C Lecis E Burra P Floreani A Cecchetto A Naccarato R. Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis. J Hepatol. 1995; 22(4): 449– 456.
  • 6Seronello S, Sheikh MY, Choi J. Redox regulation of hepatitis C in nonalcoholic and alcoholic liver. Free Radic Biol Med. 2007; 43(6): 869– 882
  • 7Ohsawa I Ishikawa M Takahashi K Watanabe M Nishimaki K Yamagata K Katsura K Katayama Y Asoh S Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007; 13(6): 688– 694.
  • 8Cai J Kang Z Liu K Liu W Li R Zhang JH Luo X Sun X. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model. Brain Res. 2009; 1256: 129– 137.
  • 9Kang KM Kang YN Choi IB Gu Y Kawamura T Toyoda Y Nakao A. Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Med Gas Res. 2011; 1: 11.
  • 10Nakao A Toyoda Y Sharma P Evans M Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome: An open label pilot study. J Clin Biochem Nutr. 2010; 46(2): 140– 149
  • 11Lee WM. Cellular and humoral immunity in viral hepatitis. Am J Clin Pathol. 1976; 65(5 Suppl): 866– 869.
  • 12Yu Y Gong R Mu Y Chen Y Zhu C Sun Z Chen M Liu Y Zhu Y Wu J. Hepatitis B virus induces a novel inflammation network involving three inflammatory factors IL-29, IL-8, and cyclooxygenase-2. J Immunol. 2011; 187(9): 4844– 4860.
  • 13Swietek K, Juszczyk J. Reduced glutathione concentration in erythrocytes of patients with acute and chronic viral hepatitis. J Viral Hepat. 1997; 4(2): 139– 141.
  • 14Tasdelen Fisgin N Aydin BK Sarikaya H Tanyel E Esen S Sunbul M Leblebicioglu H. Oxidative stress and antioxidant defense in patients with chronic hepatitis B. Clin Lab. 2012; 58(3–4): 273– 280.
  • 15Bolukbas C Bolukbas FF Horoz M Aslan M Celik H Erel O. Increased oxidative stress associated with the severity of the liver disease in various forms of hepatitis B virus infection. BMC Infect Dis. 2005; 5: 95.
  • 16Medina J, Moreno-Otero R. Pathophysiological basis for antioxidant therapy in chronic liver disease. Drugs. 2005; 65(17): 2445– 2461.
  • 17Singal AK, Jampana SC, Weinman SA. Antioxidants as therapeutic agents for liver disease. Liver Int. 2011; 31(10): 1432– 1448.
  • 18Villanueva C, Kross RD. Antioxidant-induced stress. Int J Mol Sci. 2012; 13(2): 2091– 2109.
  • 19Hong Y, Chen S, Zhang JM. Hydrogen as a selective antioxidant: a review of clinical and experimental studies. J Int Med Res. 2010; 38(6): 1893– 1903.
References
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