Hydrogen gas helps with post-cardiac arrest syndromeScientific Research

Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　– First-in-Human Pilot Study –

Abstract

Background

Hydrogen (HI) inhalation improves brain and cardiac dysfunction in an animal model of post-cardiac arrest syndrome (PCAS). HI in human patients with PCAS has never been studied.

METHODS AND RESULTS

Between January 2014 and January 2015, 21 of 107 out-of-hospital cardiac arrest patients achieved spontaneous cardiac recovery. After excluding 16 patients with specific criteria, 5 patients underwent HI and target temperature management (TTM). No adverse events related to HF were observed, and 4 patients survived for 90 days with favorable neurological outcomes.

Conclusion

HI combined with TTM is a feasible treatment for PCAS patients. (Circ J 2016;80:1870-1873)

References

1. Soga T, Nagao K, Sawano H, Yokoyama H, Tahara Y, Hase M, et al. Neurological benefit of therapeutic hypothermia following return of spontaneous circulation for out-of-hospital non-shockable cardiac arrest. Circ J 2012; 76: 2579–2585.

2. Merchant RM, Soar J, Skrifvars MB, Silfvast T, Edelson DP, Ahmad F, et al. Therapeutic hypothermia utilization among physicians after resuscitation from cardiac arrest. Crit Care Med 2006; 34: 1935–1940.

3. Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Maekawa Y, et al. H(2) gas improves functional outcome after cardiac arrest to an extent comparable to therapeutic hypothermia in a rat model. J Am Heart Assoc 2012; 1: e003459, doi:10.1161/JAHA.112.003459.

4. Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, et al. Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management. Circulation 2014; 130: 2173–2180.

5. Neumar RW, Nolan JP, Adrie C, Aibiki M, Berg RA, Bottiger BW, et al. Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication: A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Council of Asia, and the Resuscitation Council of Southern Africa); the American Heart Association Emergency Cardiovascular Care Committee; the Council on Cardiovascular Surgery and Anesthesia; the Council on Cardiopulmonary, Perioperative, and Critical Care; the Council on Clinical Cardiology; and the Stroke Council. Circulation 2008; 118: 2452–2483.