Hydrogen therapy in sepsisScientific Research

Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Yijun Zheng1 and Duming Zhu1

 

Academic Editor: Xiao-Kang Li

Abstract

Molecular hydrogen therapy has been extensively studied and studied since it was proposed in 2007. Many animal experiments have been performed in various disease areas, such as B. cerebral infarction, ischemia-reperfusion injury, Parkinson’s disease, type 2 diabetes, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, Stress ulcers, acute sports injuries, mitochondrial and inflammatory diseases and acute erythematous dermatoses and other pathological processes or diseases. Molecular hydrogen therapy is noted because it also has protective effects in patients with sepsis. The efficacy of molecular hydrogen therapy on sepsis is manifested in basic vital signs, organ function (brain, lung, liver, kidney, small intestine, etc.), survival rate, etc. Molecular hydrogen therapy can significantly reduce the release of inflammatory factors and oxidative stress damage. Thereby reducing the damage of sepsis to various organ functions and improving the survival rate. Molecular hydrogen therapy is a prospective approach to sepsis.

Conclusion

Molecular hydrogen therapy has a protective effect on sepsis, which is confirmed by pathological biopsy, inflammatory/anti-inflammatory factor levels, oxidative stress response, behavioral experiments and other organ function-related indicators. Although the effect of molecular hydrogen therapy on the liver and kidneys is controversial, the mainstream view is that molecular hydrogen therapy is beneficial to the brain, lung, liver, kidney, small intestine and other organs.

Molecular hydrogen therapy combined with oxygen therapy or fluid resuscitation can reduce oxygen free radical damage, fluid and vasoactive drug use, and fluid overload. Therefore, molecular hydrogen therapy can reduce the complications of oxygen therapy and fluid resuscitation.

However, most of the research results come from animal experiments, and there are few reports of clinical studies. More clinical evidence is needed.

In conclusion, molecular hydrogen therapy is a promising approach to attenuate organ damage, improve prognosis, and reduce mortality in sepsis.

References

  1. G. S. Martin, D. M. Mannino, S. Eaton, and M. Moss, “The epidemiology of sepsis in the United States from 1979 through 2000,” New England Journal of Medicine, vol. 348, no. 16, pp. 1546–1554, 2003.View at: Publisher Site | Google Scholar
  2. J. A. Russell, “Management of sepsis,” The New England Journal of Medicine, vol. 355, no. 16, pp. 1699–1713, 2006.View at: Publisher Site | Google Scholar
  3. I. Ohsawa, M. Ishikawa, K. Takahashi et al., “Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals,” Nature Medicine, vol. 13, no. 6, pp. 688–694, 2007.View at: Publisher Site | Google Scholar
  4. J. Zhang, Q. Wu, S. Song et al., “Effect of hydrogen-rich water on acute peritonitis of rat models,” International Immunopharmacology, vol. 21, no. 1, pp. 94–101, 2014.View at: Publisher Site | Google Scholar
  5. K. Xie, Y. Yu, Y. Pei et al., “Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release,” Shock, vol. 34, no. 1, pp. 90–97, 2010.View at: Publisher Site | Google Scholar
  6. W. Liu, L.-P. Shan, X.-S. Dong, X.-W. Liu, T. Ma, and Z. Liu, “Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury,” World Journal of Gastroenterology, vol. 19, no. 4, pp. 492–502, 2013.View at: Publisher Site | Google Scholar
  7. J. Zhou, Y. Chen, G.-Q. Huang et al., “Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture,” Journal of Surgical Research, vol. 178, no. 1, pp. 390–400, 2012.View at: Publisher Site | Google Scholar
  8. L. Liu, K. Xie, H. Chen et al., “Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis,” Brain Research, vol. 1589, pp. 78–92, 2014.View at: Publisher Site | Google Scholar
  9. L. Liu, K. Xie, H. Chen, X. Dong, G. Wang, and Y. Yu, “Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice,” Chinese Critical Care Medicine, vol. 26, no. 9, pp. 629–633, 2014.View at: Publisher Site | Google Scholar
  10. K. Xie, W. Fu, W. Xing et al., “Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis,” Shock, vol. 38, no. 6, pp. 656–663, 2012.View at: Publisher Site | Google Scholar
  11. G.-M. Li, M.-H. Ji, X.-J. Sun et al., “Effects of hydrogen-rich saline treatment on polymicrobial sepsis,” Journal of Surgical Research, vol. 181, no. 2, pp. 279–286, 2013.View at: Publisher Site | Google Scholar
  12. K. Xie, Y. Yu, Y. Huang et al., “Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis,” Shock, vol. 37, no. 5, pp. 548–555, 2012.View at: Publisher Site | Google Scholar
  13. W. Liu, X.-S. Dong, Y.-Q. Sun, and Z. Liu, “A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats,” International Journal of Clinical and Experimental Medicine, vol. 7, no. 4, pp. 919–926, 2014.View at: Google Scholar
  14. H. Chen, K. Xie, H. Han et al., “Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway,” International Immunopharmacology, vol. 28, no. 1, pp. 643–654, 2015.View at: Publisher Site | Google Scholar
  15. B. J. Dixon, J. Tang, and J. H. Zhang, “The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance,” Medical Gas Research, vol. 3, no. 1, p. 10, 2013.View at: Publisher Site | Google Scholar
  16. H. Liu, X. Liang, D. Wang et al., “Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury,” Shock, vol. 43, no. 5, pp. 504–511, 2015.View at: Publisher Site | Google Scholar
DOI: 10.1155

Published on: 20/06/2016

Authors:

Yijun Zheng и Duming Zhu

Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis

Yijun Zheng1 and Duming Zhu1

 

Academic Editor: Xiao-Kang Li

Abstract

Molecular hydrogen therapy has been extensively studied and studied since it was proposed in 2007. Many animal experiments have been performed in various disease areas, such as B. cerebral infarction, ischemia-reperfusion injury, Parkinson’s disease, type 2 diabetes, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, Stress ulcers, acute sports injuries, mitochondrial and inflammatory diseases and acute erythematous dermatoses and other pathological processes or diseases. Molecular hydrogen therapy is noted because it also has protective effects in patients with sepsis. The efficacy of molecular hydrogen therapy on sepsis is manifested in basic vital signs, organ function (brain, lung, liver, kidney, small intestine, etc.), survival rate, etc. Molecular hydrogen therapy can significantly reduce the release of inflammatory factors and oxidative stress damage. Thereby reducing the damage of sepsis to various organ functions and improving the survival rate. Molecular hydrogen therapy is a prospective approach to sepsis.

Conclusion

Molecular hydrogen therapy has a protective effect on sepsis, which is confirmed by pathological biopsy, inflammatory/anti-inflammatory factor levels, oxidative stress response, behavioral experiments and other organ function-related indicators. Although the effect of molecular hydrogen therapy on the liver and kidneys is controversial, the mainstream view is that molecular hydrogen therapy is beneficial to the brain, lung, liver, kidney, small intestine and other organs.

Molecular hydrogen therapy combined with oxygen therapy or fluid resuscitation can reduce oxygen free radical damage, fluid and vasoactive drug use, and fluid overload. Therefore, molecular hydrogen therapy can reduce the complications of oxygen therapy and fluid resuscitation.

However, most of the research results come from animal experiments, and there are few reports of clinical studies. More clinical evidence is needed.

In conclusion, molecular hydrogen therapy is a promising approach to attenuate organ damage, improve prognosis, and reduce mortality in sepsis.

References

  1. G. S. Martin, D. M. Mannino, S. Eaton, and M. Moss, “The epidemiology of sepsis in the United States from 1979 through 2000,” New England Journal of Medicine, vol. 348, no. 16, pp. 1546–1554, 2003.View at: Publisher Site | Google Scholar
  2. J. A. Russell, “Management of sepsis,” The New England Journal of Medicine, vol. 355, no. 16, pp. 1699–1713, 2006.View at: Publisher Site | Google Scholar
  3. I. Ohsawa, M. Ishikawa, K. Takahashi et al., “Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals,” Nature Medicine, vol. 13, no. 6, pp. 688–694, 2007.View at: Publisher Site | Google Scholar
  4. J. Zhang, Q. Wu, S. Song et al., “Effect of hydrogen-rich water on acute peritonitis of rat models,” International Immunopharmacology, vol. 21, no. 1, pp. 94–101, 2014.View at: Publisher Site | Google Scholar
  5. K. Xie, Y. Yu, Y. Pei et al., “Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release,” Shock, vol. 34, no. 1, pp. 90–97, 2010.View at: Publisher Site | Google Scholar
  6. W. Liu, L.-P. Shan, X.-S. Dong, X.-W. Liu, T. Ma, and Z. Liu, “Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury,” World Journal of Gastroenterology, vol. 19, no. 4, pp. 492–502, 2013.View at: Publisher Site | Google Scholar
  7. J. Zhou, Y. Chen, G.-Q. Huang et al., “Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture,” Journal of Surgical Research, vol. 178, no. 1, pp. 390–400, 2012.View at: Publisher Site | Google Scholar
  8. L. Liu, K. Xie, H. Chen et al., “Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis,” Brain Research, vol. 1589, pp. 78–92, 2014.View at: Publisher Site | Google Scholar
  9. L. Liu, K. Xie, H. Chen, X. Dong, G. Wang, and Y. Yu, “Role of Nrf2 in the protective effects of hydrogen against cerebral dysfunction in septic mice,” Chinese Critical Care Medicine, vol. 26, no. 9, pp. 629–633, 2014.View at: Publisher Site | Google Scholar
  10. K. Xie, W. Fu, W. Xing et al., “Combination therapy with molecular hydrogen and hyperoxia in a murine model of polymicrobial sepsis,” Shock, vol. 38, no. 6, pp. 656–663, 2012.View at: Publisher Site | Google Scholar
  11. G.-M. Li, M.-H. Ji, X.-J. Sun et al., “Effects of hydrogen-rich saline treatment on polymicrobial sepsis,” Journal of Surgical Research, vol. 181, no. 2, pp. 279–286, 2013.View at: Publisher Site | Google Scholar
  12. K. Xie, Y. Yu, Y. Huang et al., “Molecular hydrogen ameliorates lipopolysaccharide-induced acute lung injury in mice through reducing inflammation and apoptosis,” Shock, vol. 37, no. 5, pp. 548–555, 2012.View at: Publisher Site | Google Scholar
  13. W. Liu, X.-S. Dong, Y.-Q. Sun, and Z. Liu, “A novel fluid resuscitation protocol: provide more protection on acute kidney injury during septic shock in rats,” International Journal of Clinical and Experimental Medicine, vol. 7, no. 4, pp. 919–926, 2014.View at: Google Scholar
  14. H. Chen, K. Xie, H. Han et al., “Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway,” International Immunopharmacology, vol. 28, no. 1, pp. 643–654, 2015.View at: Publisher Site | Google Scholar
  15. B. J. Dixon, J. Tang, and J. H. Zhang, “The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance,” Medical Gas Research, vol. 3, no. 1, p. 10, 2013.View at: Publisher Site | Google Scholar
  16. H. Liu, X. Liang, D. Wang et al., “Combination therapy with nitric oxide and molecular hydrogen in a murine model of acute lung injury,” Shock, vol. 43, no. 5, pp. 504–511, 2015.View at: Publisher Site | Google Scholar
References
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