Hydrogen to patients with colon cancerScientific Research
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model<br/ ><br/ >Asgharzadeh F, Tarnava A, Mostafapour A, Khazaei M, LeBaron TW. Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model. World J Gastrointest Oncol 2022; 14(1): 242-252 [PMID: 35116114 DOI: 10.4251/wjgo.v14.i1.242]
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W LeBaron
Abstract
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide. Tumor resection remains the first-line treatment of choice; however, effective non-surgical intervention remains a high priority. 5-Fluorouracil (5-FU) is a widely used chemotherapeutic drug, and molecular hydrogen (H2) is known for its antioxidant and anti-inflammatory effects, and studies have pointed to its potential antitumor effects. Therefore, H2 dissolved in water [hydrogen-rich water (HRW)] with or without 5-FU may act as a new therapeutic agent for CRC.
Aim
To investigate the effect of HRW (with or without 5-FU) as a novel therapeutic agent for CRC.
Methods
CRC was induced in the left flank of inbred Balb/c mice. 24 tumor mice were randomly divided into 4 groups (n=6 in each group), and the treatment methods were as follows: (1) control group; (2) 5-FU group, intraperitoneal injection of 5-FU (5 mg/kg) every other day; ( 3) H2 group, the tablet that produces H2 is dissolved in animal drinking water to produce HRW administration, the same gavage administration of 200 μl; (4) combined group H2 (administration mode is the same as group three) combined administration with 5-FU The same way as group two.
Results
Administration of HRW + 5-FU significantly improved tumor weight, tumor size, collagen content, and fibrosis compared with CRC controls. Specifically, HRW attenuated oxidative stress (OS) and enhanced antioxidant activity (AA), whereas 5-FU treatment exacerbated OS and attenuated AA. Compared with 5-FU alone, the combination of HRW + 5-FU significantly reduced tumor weight and size, and decreased collagen deposition and fibrosis grade, while further increasing OS and decreasing AA.
Conclusion
Administration of HRW, with or without 5-FU, can be used as a therapeutic agent for the treatment of CRC.
References
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DOI: 10.4251
Published on: 15/06/2023
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model<br/ ><br/ >Asgharzadeh F, Tarnava A, Mostafapour A, Khazaei M, LeBaron TW. Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model. World J Gastrointest Oncol 2022; 14(1): 242-252 [PMID: 35116114 DOI: 10.4251/wjgo.v14.i1.242]
Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei, Tyler W LeBaron
Abstract
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide. Tumor resection remains the first-line treatment of choice; however, effective non-surgical intervention remains a high priority. 5-Fluorouracil (5-FU) is a widely used chemotherapeutic drug, and molecular hydrogen (H2) is known for its antioxidant and anti-inflammatory effects, and studies have pointed to its potential antitumor effects. Therefore, H2 dissolved in water [hydrogen-rich water (HRW)] with or without 5-FU may act as a new therapeutic agent for CRC.
Aim
To investigate the effect of HRW (with or without 5-FU) as a novel therapeutic agent for CRC.
Methods
CRC was induced in the left flank of inbred Balb/c mice. 24 tumor mice were randomly divided into 4 groups (n=6 in each group), and the treatment methods were as follows: (1) control group; (2) 5-FU group, intraperitoneal injection of 5-FU (5 mg/kg) every other day; ( 3) H2 group, the tablet that produces H2 is dissolved in animal drinking water to produce HRW administration, the same gavage administration of 200 μl; (4) combined group H2 (administration mode is the same as group three) combined administration with 5-FU The same way as group two.
Results
Administration of HRW + 5-FU significantly improved tumor weight, tumor size, collagen content, and fibrosis compared with CRC controls. Specifically, HRW attenuated oxidative stress (OS) and enhanced antioxidant activity (AA), whereas 5-FU treatment exacerbated OS and attenuated AA. Compared with 5-FU alone, the combination of HRW + 5-FU significantly reduced tumor weight and size, and decreased collagen deposition and fibrosis grade, while further increasing OS and decreasing AA.
Conclusion
Administration of HRW, with or without 5-FU, can be used as a therapeutic agent for the treatment of CRC.
References
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Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study. Lancet Oncol. 2019;20:74-87. [PubMed] [DOI] [Cited in This Article: 1] [Cited by in Crossref: 44] [Cited by in F6Publishing: 19] [Article Influence: 11.0] [Reference Citation Analysis (0)] 5. Longley DB, Harkin DP, Johnston PG. 5-fluorouracil: mechanisms of action and clinical strategies. Nat Rev Cancer. 2003;3:330-338. [PubMed] [DOI] [Cited in This Article: 1] [Cited by in Crossref: 2693] [Cited by in F6Publishing: 2414] [Article Influence: 141.7] [Reference Citation Analysis (0)] 6. Yang Q, Ji G, Pan R, Zhao Y, Yan P. Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Mol Clin Oncol. 2017;7:891-896. [PubMed] [DOI] [Cited in This Article: 1] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 1.0] [Reference Citation Analysis (0)] 7. 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